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KMID : 0369319930130040465
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Allergy
1993 Volume.13 No. 4 p.465 ~ p.475
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the effects of interleukin-4 and interferon-gamma on the expression of FceR 2 on B cells
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Abstract
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Two types of receptors for the Fo portion of human IgE(FcεR) differ in their affinity for IgE as well as in their cellular distribution and function. Type 1 FcεR I) show high affinity for IgE and are detectable on mast cells and basophils.
The reaction between allergen and IgE bound to FcεR I induces degranulation of basophils and mast cells, with release of chemical mediators responsible for the clinical manifestations of allergy. Type 2 FcεR(FcεR II) bind IgE with lower
affinity
and
are present on monocytes, macrophages, lymphocytes, platelets and eosinophils. The biding of IgE to FcεR II activates a variety of effector functions in these cells.
Interleukin-4(IL-4) and interferon-γ(IFN-γ) that are secreted from the T lymphocytes influence the expression of FcεR II on B cells and the production of IgE, Therefore play an important role in immunologic factors in allergy.
This study was performed to evaluate the roles of these lympokines and their interactions in the expression of FcεR II and production of solubles FcεR II(sFcεR II) on B cells.
Expression of FcεR II on B cells from normal and allergic individuals were measured by double stainings with anti Leu 16-FITC and anti Lew 20-PE and analysed with FACS. Interaction between IL-4 and IFN-γhydrocortisone in the expression of FcεR
II
were observed.
B-lymphocytes of allergic individuals showed more increased expression of FcεR II than those of % normal ones. The cultured B-lymphocytes with IL-4 showed increased FcεR II expression in both groups but there was no difference between them.
IL-4
induced FcεR II expression and production of sFcεR II were inhibited by IFN-γand hydrocortisone.
Thus it may be concluded that the interaction and important role in the immunopathogenes of allergy
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KEYWORD
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